Can't really think of why it may be doing this, so I'd just try a bunch of stuff, like...
1. Are your other game settings being saved?
2. If you change something else, does it work (like 16-19)?
3. Are there any weird values in the settings (something other than 00 thru 03)?
4. Reset all audit settings one-by-one using the button on the MPU (basically, classic Bally version of a factory reset).
5. Check connectors between sound board and MPU.
things you may not be able to try, but might also help isolate the problem...
Swap MPU with another
Swap sound board with another
Swap 5101 with another
Swap ROMS with others