Often, disliking a game has more to do with not getting the game, or the game not being properly set up. There were games that I disliked, but when forced to play them in league, I have grown to like, or at least tolerate them. There isn't really a single game that I really hate. Episode 1 has a dull ruleset and layout, but at least the machine looks good and the integration of CG is pretty good, for example. Although, I never choose to play it, unless I have to in a league or tournament.
Of course, there are aspects of a game that can detract.
Poor artwork: Space Jam, Shaq Attack, Raven, Diamond Lady, DM.
Poor rules: SP, Episode 1, SW, Popeye, Rocky and Bullwinkle (in tournaments), IJ4.
Boring toys: CP, Popeye.
Poor theme: BBH, Nascar.
If I had to choose a least favorite, it is probably Popeye.