Have you run through the solenoid test mode?

sounds like power supply issues. Measure your voltages with your DMM and report back. Seems like the game is resetting or dying under load which will take out that fuse as you will get one or more locking devices when the computer stops running.

If power supply has never been touched I can guarantee the caps need to be done at a minimum.

Check the diode(s) on every coil under the playfield including the flippers. A broken coil diode could cause resets, blown fuses, etc.

I also found a whole list of stuff to check from Clay's Guide:

Put the game in diagnostic switch test, and press all the playfield switches. Make sure no one switch activates two switches (or more) on the score display during this test (indicating a switch matrix problem, which can slam tilt a game into a reset).
Check the +5 volts on the CPU board with the game in attract mode. Should be 4.9 volts to 5.2 volts DC. If it is not in this range, there is a power supply problem (even if the voltage is in this range, there can still be a power supply problem!)
Check the input (wall) voltage to the game. It should be in the 115 to 125 volt AC range. If it is below 115 volts, resets can occur.
Check the power supply fuse holders F5 and F6. Sometimes these can tarnish or crack, or the fuses themselves can become resistive.
Replace the +5 volt filter capacitor C10 (18,000 mfd, 20 volts) on the power supply. These games are 15+ years old, and these filter capacitors have an approximate lifespan of about 10 years. So every system11 game is really due to have this capacitor replaced!
Replace the power supply capacitor at C8 (47 mfd, 50 volt). This cap often goes open and will cause a low +5 volts.
If the +5 volts is still low or the game is still resetting, replace the power supply bridge rectifier BR1. This is a 35 amp 200 volt lug lead bridge.
If the +5 volts is still low or the game is still resetting, replace the +5 volt Darlington transistor on the power supply at Q5 (2N6057, but replace with a 2N6059).
If the +5 volts is still low or the game is still resetting, replace the +5 volt regulator chip on the power supply at IC1 (MC1723C, also known as a 723C).
If the game is still resetting, look for cracked solder joints on the backs of the connector pins on all of the boards in backbox. This is a common problem and can cause reset as well. The most likely connectors to cause reset problems are power supply connector 3J6 (power out) and CPU connectors 1J17 (power in). Resoldering these circuit board connectors.

Test point #3 is the reason you are having resets. This should be reading @ 12.6 volts dc. The bridge rectifier on the power supply maybe starting to good bad.