If you're asking in competition, it's becasue you have to make rules to limit playtime. If you have a way to bring the ball back in play you could play all day. If I was playing on my TZ I could bang-pass from the right out to the left, and then bang back pretty easily back in the day, that would just be recockulus in a tournament.
Obviously other things mentioned already like damage, DQs, tilt-thrus, moving the machine too far etc etc.
If you mean in you own home, I don't care. Obviously there's a big group of people on pinside think tilting is cheating so i wouldn't listen to them too much.