Dr Who isn't even human. It was already canon that Timelords can and will shift genders, and indeed can regenerate into species other than pseudo-human, in which case the gender bending would get even more weird(what happens for species with more than 3 genders, or no genders?).
I frankly don't care much either way. If the story is worth watching to me, I'll watch it, reboot or otherwise. If not, it will die. No skin off my teeth.

Now, when are we getting a Manimal remake?!

There was objections to that because of a specific situation in the second book, which dealt with racism. But, given that the movie wasn't meant to be an direct adaptation of the books(it's a sequel to the books), this was actually fine. And Elba and McConaughey were great in their roles of Roland and Walter. The screenplay was bad(too compressed). But, there was also a lot of blow back for Roland's race that had nothing to do with the interactions with Detta.
Frankly, aside from the occasionally racism or sexism that pops up and warrants some discussion, it mostly bores me. For example, when I was a wee lad, I loved Transformers. Michael Bay pretty much screwed that whole mythos up with his stupid movies. BUT, I can't bring myself to give much of a shit. Bay can't change the originals, and I'm not obligated to watch his crap. So, why should I care? To bring this back on topic, I can watch the original MPi. I don't have to care about this version, and it doesn't make a lot of sense to get worked up over it, regardless of my feelings for the original.

I keep getting stuck on Higgins and "throbbing."
"Higgins is so hot right now" - Mugatu