Resident Evil and Avengers are neck and neck for me theme wise. Voted RE only because it's been so long since there has been a horror pin. And Milla ALWAYS wins.
Of course you throw in Star Trek, and that probably bumps both of them. Other than the Milla factor. Makes it a tough call...
Between those three it will really come down to who is at the helm (I really, really want to see Borg Unleashed the way Ritchie was with ACDC!!) and what the layout and art is like.
Don't get me wrong...Muppets and MIB would both be awesome themes as well. Can't lose with any of the current major rumors in my book!