Concentrate on the wed modes as mentioned, and try to stack as many modes going into multi-ball.

When concentrating on web modes, I've found the sandman and goblin are generally hit throughout the play. Venom and Ock take a bit more targeting. As mentioned, you don't have to complete the web modes...just start them. But they are good points if they can be completed (x3 multiplier I beleive)

Once I get into multi-ball - particularly if I have the first two venom modes completed, I will simply take shot after shot at the side ramp/venom - letting the balls drain - until ball-save light goes out. This allows you to catch up on venom if behind on its progress. Obviously not kosher for tourney play.

The real points come in from stacking modes. Because no multiball mode ends until there are less than two balls in play, it possible to get a lot of points by stacking and getting multiple multi-ball modes going. I will generally try to stage this as best I can. Get black-suit locks built up, a web mode ready to go, and a number of villian hits made or modes stated. Then I start the web mode (can't be started in multi-ball) - preferably bonesaw as its best suited for multi-ball - finish getting the black suit locks to start it, and then start drilling the villains to get those modes going. I've gotten nearly 400M pts during a single multi-ball by having both black suit and Doc Ock multi-balls modes going, completing the web mode and a number of villians, and starting new multi-ball modes while still in multi-ball. Being able to complete the super jackpots during multi-ball (and stacked multi-balls) also tends to bring big points....but its difficult to make all the shots - or even knowing which need to be hit - while keeping track of all the balls.

Once the multi-ball modes are running, you only have to keep two balls in play to keep the (multiple) multi-ball mode(s) active (and associated scoring). As such, I tend to concentrate on really only saving two balls rather than all four when things really start to fly. Normally I will hit both flippers to skip a lot of the sounds, animations and ball lock when a ball gets trapped (e.g., completing sandman or doc ock) because I don't like it interrupting the flow. However, once I start a multi-ball, i never get a ball to release before its done. While its being held, its one less I have to deal with for the time being.

+1 - The couple times I've made it to SH has been when concentrating on white modes and they have not been particularly high-scoring games. I haven't managed to get thru SH yet, so I don't know what sort of silly bonus points could be had.

My highest scores (up to 660M, but generally 450/500M) have always been by stacking modes/multi-ball and getting the various associated super/jackpots. There's so much to do in this game, it allows so many ways to approach the game play.