I'd like to see a new Western theme game.
I'm normally not a huge fan of S. King, but I think something along the lines of Dark Tower would have some amazing imagery that could be used. It's also obscure enough that for the majority of people it would basically feel like an original theme.
The one thing it's missing is "campyness". In many ways this machine would need to be dark, twisted and creepy. Because it's based on a series of seven books the ruleset could and should be epic, like Lord of the Rings.
http://www.digitaltrends.com/wp-content/uploads/2011/10/dark-tower-via-bloody-disgusting.jpg