A lot of real niche things being listed here. To get MAXIMUM interest? You need a big license. I think all of the following would be big and I would love to do any of them, so I guess I would go with whoever was easiest to get/deal with. Leaving out Star Wars and Alice in Wonderland cause they are already happening.
World of Warcraft
Dungeons & Dragons
Call of Duty
Super Smash Bros.
Legend of Zelda
Silence of the Lambs
Gizmo and the Gremlins
Spawn (Todd McFarlane art package...)
Hipster picks for the fun of it:
Labyrinth (I would love this so much...)