I'd like to see one where you play as the villain. I'd imagine you could do all sorts of fun tricks with magnets in a Magneto pinball machine. Magneto multiball was really the only redeeming part of the X-Men pin and I think that was only on the premium and LE.
And while it wasn't exactly a comic book, Calvin And Hobbes would be great, but Watterson refuses to even license them out for shirts. His prerogative though.