Yes https://retropie.org.uk/

MAME is just a PC and you can connect to anything...the real issue is where you put the controller section, whcih ends up being pretty big

EDIT: Or nevermind me and look above

If you wanted to engineer a solution you could get one of those fighting game sticks, or build one, and then put a retropie in. Then boom, MAME on any TV with arcade controls. This is also something people sell pre-made, so you could just buy one too

ebay.com link: Raspberry Pi 3 Video Game console Retropie in an Arcade Fighting Stick MAME

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I've been thinking of doing something similar. Can someone who understands it basically explain the differences/advantages between a Retropie and Pandora's box set up?

This is one of the few times you'll hear me say this, but check Craigslist. There are a lot of guys out there putting together cheap mame and retro-pie systems in old arcade cabinets or as just large controllers built in. If nothing else, it will give you a good idea of what is available. Most of those 3000 in 1 machines you see use unlicensed games. Trying to get everything together yourself is a good way of accidently loading your computer up with malware. If nothing else, it can give you a good idea of what is available.

Retropie is more or less the front end that runs off a raspberry pi and it comes with all the emulators loaded (you still need ROMs) but its basically very minimal work to set up (drag and drop ROMs to a folder on an SD card, plug card into Raspberry Pi and it does the rest). It supports most consoles and MAME through the Playstation era. It has hdmi and bluetooth so it's very versatile and cheap to play around with.

The downside is that the Raspberry Pi is just that, not very powerful. I have one built that I use on my TV in my family room and there's very noticable button input lag. It works and it's fun to mess with, but it's not great.

Pandora's box is basically a pre loaded board you can buy and throw in a cab. It runs better than the 60 in 1 board but some games are hit or miss on performance and sound, but its literally plug and play and has a deep selection of games so alot of people use it.

If you want to have the BEST multicade experience, I'd recommend building (or buying) a hyperspin setup. It's not a quick build, but it will give you a super slick interface, all consoles, mame, etc, and the best performance.

Thanks for the explanation, that was helpful!