A rottendog CPU board is actually not 100% new. The WPC CPU ASIC has not been manufactured in 15+ years. So, you're either using a used pull, or a NOS piece, which exist but are getting harder to find.
I've heard a few stories where people had issues with Rottendog boards. I admittedly don't have much personal experience with them, as I repair boards, and a guy who repairs boards doesn't really have much experience with repro boards.
Based on past precedent, I would *not* plan on putting Rottendog boards in a game and have it be the silver bullet that solves all your problems. I *would* suggest replacing all the ribbon cables in the backbox, as 20 year old ribbon cables have deteriorated over the years and will cause all sorts of wacky problems that are fun to try and diagnose.
You would also want to look pretty close at several connectors in the backbox that will deteriorate, GI input and ouput, secondary input, Z connector between the CPU and driver, etc.
I also hate fuse clips with a passion, and that's what RD uses on his boards. Probably comes from replacing them left and right over the years on DE power supplies and WMS sound boards.
Parts fail. New parts fail. Old parts fail. RD uses pulled 6821s on his boards that use 6821s (TZ doesn't use any...).
Nobody in the world can guarantee a part - new or old - won't fail in a week, month, year, etc. We can certainly look at ratings on a cap, or pull based on our experience, but there will always be some that outlast others, and some that fail before others
Do whatever makes you comfortable. I don't repair boards because I find it's the cheapest choice, I truthfully feel original boards in good condition are the *best* choice. But you get to make that call for you, just like I get to make it for me. Thankfully, it's a pinball machine, so whatever you decide isn't a life or death decision