Just saw this....sorry.....
Yes, Sierra Nevada a must.....even if you don't get the " full" tour, the mini one is cool...and the food is great in the restaurant ( reasonable priced) along w the beer....
Micro brews everywhere....I recommend HiWire...they've got a hidden spot on biltmore ave., behind golds gym.
The downtown culture is very artsy and safe, day and night, with some great food hidden away ( some amazing BBQ)
If you are coming in the Fall, make sure to get reservations wherever, as it gets busy. The Omni Grove Park Inn has spectacular views, and major league spa.
Biltmore village just south, lots of boutique shopping.
PM me if you'd like, and can share what I know....mark