Quoted from semicolin:
Yes. You will need a brand new set of new OV+N95 cartridges for each single application of clear. For example, five coats over five days and a couple of dropper touch up sessions is going to be seven new pairs of cartridges. The chemical neutralization agent may be good at clearing some components for a whole day, but they are only effective against other ingredients for a short time, and then the agent is used up.
This is why everyone involved, from the pinheads at the top of the thread, to the respirator manufacturer, to the producer of 2K Auto clear all tell you straight up that you might as well go out and buy a supplied-air respirator, since it will last you many applications and will never expire.
From Nexreg (the manufacturer of 2K), here are the components of 2K Glamour, and beside it, the minimum cartridge requirement from 3M:
Dimethyl ether 39.70% : Supplied air or OV(Short life ONLY)
Acetone 20.11% : Supplied air or OV(Short life ONLY)
n-Butyl acetate 11.87% : Full mask OV
Hexamethylene diisocyanate homopolymer 6.18% : OV+N95
Xylenes (o-, m-, p- isomers) 3.21% : OV
Propylene glycol monomethyl ether acetate 1.21% : OV
Ethylene glycol monobutyl ether acetate 1.09% : OV
Ethylbenzene 0.8% : OV
This cannot be used with half masks, as the n-Butyl acetate is quickly absorbed through your eyes and exposed facial skin. n-Butyl acetate is known to cause acute(immediate) symptoms and damage to your central nervous system.
It causes immediate damage to your brain.
This cannot be used with OV cartridges alone.There must be an N95 filtration component due to the content of Hexamethylene diisocyanate homopolymer. This is essentially airborne uncured rubber. The N95 pre-filter separates the particles of this in the air before they clog up the OV cartridge. Using an OV cartridge alone will result in the cartridge almost immediately being gummed up with polymers, rendering it useless and allowing everything through.
Cartridges cannot be used more than 30 minutes after the seal is broken: Dimethyl ether and acetone exposure render OV cartridges useless shortly after initial exposure. 3M recommends supplied air for this reason:
They do not trust their own cartridges to help you for more than a few minutes. They would rather you be safe than sell you extra cartridges. It is that bad for you.
tl;dr: In conclusion, the minimum cartridge protection for any level of exposure to the 2K product, regardless of open air or in a booth, is full face mask coverage coupled with cartridges marked OV/N95. Do not install one OV and one N95 cartridge. They must match. They must be replaced every time you spray a new coat or touch up, and 30 minutes after opening. If this seems like too much expense and trouble, use a supplied air respirator system with a full mask facepiece.