I have been holding off saying anything, because I know that sometimes 'noise' can be bad and help get away from the real issue, but I thought I'd share something -
I was running v24 (the 7-digit OS) for over a year now. On original hardware (do not know if my MPU had that trace fix or not) - without any issues. No sound issues at all.
Then, at some point back in this past December or January, it started showing the sound issue. I went ahead and rebuilt my SB-300. A LOT of chips for replaced (almost all of them, except for the timer), and caps all got replaced. This did NOT fix the issue.
Then I went ahead and got @barakandl 's MPU board. (For two reasons - to have a good 'test' board to swap out if needed, and to see if it helped with this.) Setting the DIPs to the v24 on IT (not sure if code was identical), the issue did NOT go away.
I have NOT replaced the timer on my SB-300 yet. That is next.
However! Here's something interesting. Back in May, had guests over, and was playing multi-player games. Everything seemed to be fine - except for the audio. A couple weeks after they left, I turn the game on, and notice that my HSTD is .. corrupted. Displays read "5<space>438". I have yet to reset the board, but.. thought I'd mention it in case it was important.
Also - at some point between the start of v24 and now, I replaced the sound cable. My **original** cable was ALL pins. The replacement I got was only 32 pins. (Hey, @barakandl - remember I mentioned a long time ago to make a second adapter for the audio cable, allowing it to use a ribbon cable? So in case new sound boards are released, it'd be easier to hooke them up? And you said 'nnaaah' .. and now you made a sound board, even, and STILL can't use a ribbon cable. )