Quoted from Kneissl:Audio feedback on these combos would kick serious ass...
I've gotten a few combos and they indeed had callouts. I'm pretty sure it is dependant on if a mode is running and what other audio is going on at the time. They definitely have a low priority, which is probably for the better. I've gotten a Kirk combo where the computer announced "USS Enterprise Captain James T Kirk" or something like that.
I'm also 90% sure that the "Dammit Jim I'm a doctor not a pinball wizard" callout is for the Bones combo.