TMNT was the first game I ever owned, and it took me maybe a day or two to realize it was a mistake. I sold it after about 2 months.
The Simpsons - Love the artwork, but a few dollars at the arcade was about all it took for me to decide it wasn't for me.
The flipside? If the price is right, buy it, and if you don't like it, sell it. I think both are about equal as far as gameplay is concerned.