Yep, it definitely does (or can) IMO. There are enough people that justified or not, look at reimports as less desirable. I'm one of them, although I am starting to come around. But, all things equal I will take the US version everytime.
Although condition is king, I think it's more likely to be in worse shape since it made the trek across the ocean and back in a container.
I think you could get the same price as a domestic, but I think it will be a harder sale because there will be less demand (buyers that are turned off by reimports) especially if its a title that is readily available as a domestic. I sell a lot on Ebay and there would be less potential bidders and that usually equals a lower sale price.