Quoted from vdojaq:

Ford Trucks, buy any of them as long as it has the 5.0L V8. The Ecoboost turbo engines are JUNK. Those 5.4 3 valve Triton engines that blew spark plugs are a long time gone. Rust issues are still a problem. 3.7 V6 is the same family as the Ecoboost engines and they ALL have serious timing issues due to poor design. If for some reason you do like/want and Ecoboost, run FULL synthetic oil from day 1 and change it every 5000 miles, it should be OK. FORD is completely off in the engineering department and their oil change intervals on ALL of the Ecoboost products.
GM/Chevy trucks, I personally don't like any of these. Transmission issues, leakers, and terrible rust issues. V-6 is horrendous. Dexos oil requirement is for FULL SYNTHETIC oil , anything else is a crap shoot on these engines.
Dodge/Ram, I honestly have to admit these are the most reliable trucks out there right now. However, don't walk away, RUN from ANYTHING with the 3.6L V-6. The Cummings Diesel is the best of all of them. Ford & Chevy can't touch the Cummings. If you buy a Hemi, use nothing but Synthetic oil.
With ANY of the domestic trucks, plan on ball joints AND tie rods generally between 80 - 100K miles
Nissan Titan.....horror stories a plenty.
Toyota trucks are very reliable, but a bit under powered.
Honda Ridgeline, new style, like them very much. Very Solid truck
This is all basic overviews coming from a repair shop owner.

Quoted from dung:

I question this as well. My experience with them is that the cummins diesel won't die, but the truck will fall apart around it. FCA products tend to have a poor reputation for reliability as well.

Quoted from vdojaq:

You are right, I should clarify. Of the big 3 , I believe Dodge/Ram trucks since 2014 to be the most reliable of NEW trucks. The older doge rams are some of the biggest POS on the road. These damn Fords are blowing timing at 90K and have huge carbon issues on the engine valves.
This hard for me to say because I am 100% a Ford truck guy.
Toyota>Dodge is also correct.