Quoted from soren:A short comment to the post about ColorDMD. Of course the goal is to work seamlessly with ColorDMD.
I do not wish to speak for them or how robust their system is. But I will say this. I have both removed and changed text on the DMD in various games. And those particular DMD sequences have still been colourised correctly. One example of this is the right ramp "x ramp shot" advertisement in Creature where an incorrect Snack attack one is now removed.
It really depends on the individual person that did the color. Some screens are recognized using the entire frame so any change would cause it to no longer be colored. Usually though frames are being identified using a small portion of the frame that typically remains static and dynamic areas are avoided.