I haven't heard the custom callouts that Karl did for ST, but there are definitely times when they can be very effective and add a lot of personality to a game! Raul Julia & Anjelica Huston did a fantastic job on TAF! I have always especially loved the energy that Julia's callouts added to the game.
I can see someone like Dan Aykroyd doing an awesome job on callouts for Ghostbusters! He naturally brought a lot of enthusiasm to that role and I could see his Stantz-isms and other paranormal techno-babble fitting in nicely! If the player was treated as a "rookie Ghostbuster" like in the video game, then the way Dan coached you through the levels would work out well for the pin!