I realize most people haven't seen a Heighway game in person yet, but the screen on Full Throttle just isn't a big deal as far as messing with gameplay. It's not like it's strobing constantly trying to distract you why you shoot.
My only complaint really is that I'd like to see them come up with a cooler way to integrate it into the playfield than a boring rounded rectangle. It feels just dumped in. If they masked it a little bit to make the shape feel more integrated, and built their graphics around that shape it would look a lot nicer IMHO.
I guess we'll see how they do it with Alien.