Flash Gordon is definitely up there, I rarely have a game where everything feels good. If you play one and don't think it's tough, that game needs to be properly setup cause it will own you. Paragon, though a much slower player, feels the same.
Of course these are both games I now own. There are lots, Mata Hari and Harlem come to mind. In fact, I'd say Harlem Globetrotters is as mean as FG sometimes, though it doesn't quite punish you for making your shot the way FG does.