I have identified the boards, re-seated all connectors, pushed on socketed chips - fuses all look and test good. Speakers have a very loud hum/buzz when starting up but it mellows out slightly as it's running, but takes several minutes.
I'm going to start testing power output on PSU and PS AUX boards. I've not found anything on a cursory search of the System 3 or this game to point me in the right direction, but I'm thinking ground issue or power or busted diode?