I built a MAME arcade about 6-7 years ago and really wanted lightgun support. Took me a long time then to find a good 27" tube that had s-video input to get a decent resolution for it. I had to take the tv apart to get it to fit inside the cabinet, but the end result with a bezel is it looks awesome and just like an arcade.
The guncon2's were the only ones i could find that worked and some random person had built a driver for windows xp. However i Still have to manually built a power circuit to power the gun from the computer power. Took a lot of time and effort but the end result was very nice and it's always a blast to fire up the arcade and some some gun games.