Quoted from Zora:
....so anyway, the information from the skull position In the respective chapter would be restricted, even if the 5 chosen chapters are known. I could select a green chapter by shooting the chest X times until the green skull is one the position for the chapter I want to select (which may be a chapter with many characters to hit before MB start). But the game makes a random select between the qualified colors or I open the green chapter only, but then I get a small multiplier only, which is a disadvantage against the advantage of choosing a special chapter in the green color.
For me the skull information therefore seems to be of minor practical importance.
You are correct. The position of the skull and which chapter begins is of minor importance. It seems to me that a lot of the Red chapters have the most character shots. There is an interesting risk/reward to lighting multiple skulls before starting a chapter. You can just light a single skull to start that color to advance towards a Wizard mode, but your chapter shots will only be 1x and not worth much. Conversely, you can focus on lighting 4-5 skulls before starting a chapter so your chapter shots are 2.5 or 3X, but you will be very unlikely to reach a wizard mode. You also might drain while trying to light all those skulls.
For these considerations, I like playing as Tia Dalma and Elizabeth Swann. But honestly, the majority of the points seem to come from stacking multiballs and Super X's, so the whole chapter thing is really secondary if you are playing for score.