Though I think the movie itself was hobbled by not having Tim Burton at the helm like planned, it's still wicked, creative, and funny, and I wouldn't be surprised if it had been kicked around as a theme concept at some point when it was new. It'd be even cooler now that we have LCDs, and the game basically creates itself - "survive" a series of satirical TV shows to battle Spike while receiving help from your kids, who are watching, and Spike's rebellious underlings. Imagine it - a Sado-Masochistic Theater 3000 mode with little devil-horned Mike/Bots on the bottom of the screen, heckling the player.
Also, less likely but still fun - "Amadeus Superstar", in which you play a pop-star Mozart on his rebellious, outrageous exploits, rising in the Viennese music scene, featuring his music revamped with a pop edge. There could be a little toy piano in the lockbar where you have to mash the lit chords with one hand to light multipliers, or something. Receive mystery awards from the hooded stranger, build your popularity, and eventually battle Salieri to claim the music throne.