Shoot the strobing shot! I've never been that bothered by the callouts in this game. Either I have a high tolerance, or partially deaf. I can tell you that my 5 year old always tells me to "Shoot the ball carefully" or "enter the Sarcophagus", so it must be somewhat repetitive.

I do find myself responding on ocassion. I'll say something like "I'm trying!", "What do you think I'm doing?", or sometimes "There, you happy now?!"