I have a SoftTopper on my 2015 Colorado ext cab. (before that, on a 2007 Tacoma)
Biggest issue Ive had is space between the wheel wells is too narrow for 2 modern pins side-by-side.
(Single pin moving piece of cake.)
I can fit 2 older with heads removed fine (one head in back seat).
Or one newer, one older, if I flip older on its side... Then they fit between wheel wells.
Obviously, with the soft topper folded back, you can stand modern pins on their back, and fit much more. But your exposed to elements.
Full sized pickup truck may have more space between the wells. Measure truck before buying.