NOTE: if you have 10B points already, Quill 2 shot starts at 1B. But you have to get the 10B points first. That's a bit of a problem for setting up a single big shot. So my requirement for 1 big shot is, it must be done BEFORE Xandar.
I have recently started playing my GOTG to set up the one big shot. There are really only two shots that qualify: Quill’s Quest 2 (scoop), and Sibling 2 (right ramp).
Quill’s Quest doesn’t need to be completed in one go to make it valuable; but it's a hurry up. So it’s a matter of playing it after Immolation Initiative, during Groot multiball, with 2 balls locked (3x), and the shot multiplied (2x), and if you are really brave, you can try to start Rampage (2x). Max multipliers comes out to 12x. With 1.5B points, the Q2 shot comes out to a 1.8B shot. Since Rampage is so hard to hit, and set up along with Groot MB and locking balls, I would only attempt if I was just one shot away from Rampage - making the shot a mere 900M.
My best Q2 shot is 600M (shot multiplier, plus 1 ball locked during Groot MB, with 1.5B). BTW, this was after Immolation, but before Cherry Bomb.
That said, that’s a lot to set up: partially complete QQ, getting to Immolation Initiative, 2nd (or 3rd) Groot MB, then everything else listed above.
Sibling 2, on the other hand, can be done MUCH earlier in the game, the shot is NOT a hurry up, and can be worth 100s of millions. Here is how: work to lock 2 balls, hit the Guardians target to be within 2 hits of lighting mystery award, shot multiply at least the right ramp (preferably left ramp too). Once this is all set up, start Sibling Rivalry, lock ball 3 to start Groot, put a ball back into Groot (for 2x), work to complete Sibling, and finish Guardians target for mystery Add-a-ball. With 2 balls locked and right ramp shot multiplied, you could have a 70M shot at 6x (or 420M points). If you start Rampage, you could be at 12x for 840M points.
I’m not sure how many points can be scored in Sibling Rivalry. My best so far is 270M: 67.5M shot at 4x. I got the Add-a-ball, but drained so I was only able to lock 1 ball.
The nice thing about this Sibling 2 big shot is, you can continue on and combine it with a bigger Quill 2 shot.
How many points have you scored on Sibling Rivalry? Also, this has changed my overall strategy. I used to play Pod Chase in Groot MB. I don't do that any more. I do Sibling Rivalry during 1st Groot MB, and Quill's Quest during 2nd Groot MB. Thoughts?