One of my very first games ever playing ghostbusters and the scream happened to me.
It actually startled me. And afterwards I just thought it was really cool.
Then... It really didn't happen too much to me the next few times that I played it.
Now, someone brought a ghostbusters to MGC. After I put up a monster game on it, I moved to the next machine(as its packed and I never camp when its crowded), and a young kid got on the machine after me. I was on the machine next to it as it was free. And the scream occurred.
I watched the whole thing from the corner of my eye.
The kids reaction was priceless. And his father was right behind him, and chuckled at his kids response as well. I think me and him shared a nod and a slight laugh ourselves. Really cool to witness the scream when you know its coming.
Can it get old... Sure... But, can't most things.