Quoted from wtatumjr:
It's probably to leave the glass off a while after adjusting flippers and play it a while. I've found when you help "this" it might hurt "that" - If you increase the cradle ability of the left flipper you might make the left flipper to right ramp shot almost impossible. It's best to find the right compromise for you.
Great advice in general. I will say aligning the flippers with the inlane on GB provided the single most improvement to game play for me. As mentioned, it gives a fighting chance at catch and cradle. I did not notice any additional difficulty to hitting the extreme angle shots (gear targets and right scoop). So for me tat least here have been no negative trade offs.