At an absolute minimum, my policy is never use alkaline batteries at all. Use AA Lithiums. They pretty much never leak.
Remote holders are also cheap and take almost no time to install and move the batteries away from the MPU board.
NVRAM when possible is usually best of course.
Alkalines are unreliable and I suspect the market has been flooded with bad quality fakes (or just bad quality batteries) for years.
Death Sticks
RM