Having Professor Knowby as a narrator would work very well. He could introduce various chapters guiding you though the Necronomicon.

I agree. Evil Dead II redid most of the iconic moments from the first movie, plus added some of the more fun campy moments without going over the top. Those include the possessed hand and chainsaw replacement. The third movie does have some scenes that would work. The "mini-Ashes" would be a fun multiball. It also has some of the best quotes: "This is my...BOOMSTICK!", "Yo, she-bitch! Let's go!", "Shop smart, shop S-mart", "Gimme some sugar, baby.", "Honey! You got real ugly!", "You ain't leadin' but two things right now: Jack and shit, and Jack left town.", etc.

I also agree with this. Having the game based on the found recorded translations of the Necronomicon would open it up to Ash vs "any form of evil". The Necronomicon is directly from the works of H.P. Lovecraft and has been used in both Evil Dead and Friday the 13th...thus the crossover comics. Though they have also done Dracula, Martians, Xena, and Hitler. Personally, I wouldn't want to wrap in another theme. I'd take a few of the scenes from Evil Dead and then create new chapters that fit into the same world. I would for sure include: possessed girlfriend, cellar door, possessed hand, and mini-Ashes. Bruce Campbell is the only major voice actor you'd really need. Having him to create custom quotes would be amazing. Any voice actors could play the various Deadites or Professor Knowby. Turning to google, the professor was already voiced by multiple people: Bob Dorian and John Peakes.