As long as we are posing hypothetical situations...
What if science progresses to where they can precisely identify the specific individual (much like with DNA) who passed a disease on to another person.
Congress then passes a law (which is tested and upheld by the Supreme Court) making it a crime if a person chooses not to be vaccinated and thereafter passes an illness on to another person, with a mandatory charge of manslaughter if the infected person dies and lesser charges if that person survives.
Civil damage claims become so lucrative that Glen Lerner redirects his entire law practice to suing the non-vaccinated disease spreaders.
Then would you consider getting vaccinated?