Quoted from 85vett:
Megaboom is good for Ninja or Mechsuite MB as it basically gets you almost to a super with one button press. If going into Mechsuite I generally hold my megaboom (or all my booms) until I get a playfield multiplier going.
For me, I actually prefer using the booms to progress through the battles vs the quest. With battles your final shot score is determined by how much life Deadpool has which is related to how long it takes you to complete. Thus I try to finish them as fast as possible. With quest, that is not the case so I tend to take my time in a quest.
For me, the absolute best time for my use of booms is on the second batch of battles. I use them to complete the Sauron shots a lot of the time.
But I do agree, I don't find as much benefit with the megaboom as I do just having seperate booms available. Because of this I will watch my booms on the display and if I have 3, I will purposely not collect the 4th. If I'm in MB, I will generally use a boom as I collect them so I stay at that 2 or 3 boom bank.
Interesting. I may have to try this strategy!