Very common in California to rent an RV. Based on the parent website, its not out of the ordinary in many other states.

http://www.rvrentalsofamerica.com/arkansas-rv-rental.aspx

Hi Jonathan/unigroove,

Pretty major road trip. Could be epic fun, or could be a real bummer.
Looks like 1650 to 2000+ miles each way depending on which way and where you are headed, and stops along the way.
24 to 30+ hours driving each way.
Weather concerns: heat in summer, snow/ice in winter.
Road construction delays are usually worse in the summer, but always something to consider in route planning.

You will want to avoid having this happen:
camper-low_bridge-wreck_(resized).jpg
camper_trailer-lowbridge-wreck_(resized).jpg

Yeah, people here do it all the time... Great way to see the country. Much better for someone who might have trouble flying as they age. After my parents retired, they traversed the country many times in a RV. Go for it, you will meet some interesting people. Just think of the Griswolds, but watch out for cousin Eddie.

I just looked into an RV excursion for 2 weeks across the US, it was so expensive that I considered buying one and than selling it when I was done. They charge by the mile.