Quoted from Eric_S:A terrible layout is permanent. Software can always be improved later if you have a great layout.
While I agree, the first game that came to mind for me was KISS. KISS has (what I would consider) a good/great layout. It's a really fun shooting game. With that said, the code is horrifically bad. Given the time between updates, I don't know how confident I'd be in an upgrade. That game could never last in my collection with that code, regardless of how it's laid out.
I think the argument is really six in one, a half dozen in the other. I don't know that I could honestly chose between either. They're both deal breakers.