The problem can be on the CPU board. The sound/speech are generated by ground signals to the sound board sound select pins that are originated by a PIA on the CPU board. PIA 5/ IC36 provides the sound signals and display commas. Do the displays still have commas when the problem occurs?
When you have the problem, don't push any buttons, just remove connector 10J3 on the sound board - machine on but with sound problems. With a clip lead, one end to the ground braid, ground pins 2,3,4,5, and 7 while you have the problem. Do you get sounds? Yes, the problem is with the CPU/PIA or connectors 10J3 or CPU connector 1J8.
If you don't get any sounds then the problem is either with the sound board or speech board.
The sound board send sounds to the speech board that are mixed with a pot to control speech/sound balance, op amped on the speech board then returned to the sound board for the main amp that you note is hot on the sound board.
To determine if the problem is on the speech board, temporarily add the option strap W1 on the sound board and disconnect the speech board. This will permit the sound board to operate independently of the speech board.
Operate the game and see if the problem presents itself. If it does not, the problem is on the speech board. Check the sound/speech balance pot and the op amp.
If the problem presents itself the problem is with the sound board and not the speech board. I would suspect any sockets first.