Wow lots of great ideas! Yes it's important to keep in mind this would be like WOOLY or TOTAN. And yes I'm a very sarcastic snarky person but if I set out to make a "serious" Bible pin it would stay consistent with that theme. (there could be jokes of course but within the source material not at the expense of it) I also did AMH, but am working on a serious horror film - it's all about sticking with tone.
A big reason to do it is rules. Once you think about it at all, they really write themselves (as Hilton said everything is numbered and most people are at least familiar with the stories) and a game designed from the "rules up" has great potential.
I'd also like to make each mode "three deep" and depending on how many phases of how many modes you complete that unlocks up to 3 Wizard modes (I know AMH lacked depth in that area)
So for instance you'd advance the 10 Plagues to start Exodus MB, completing that is Phase 1, Phase 2 you collect the 10 commandments, Phase 3 you wander the desert for 40 years. We could use color RGB inserts to light Red, Green Blue to show phase level of each mode completed.
PS: We worked "LION MAN!" into Rob Zombie, I see no reason it can't find its way into this.