Quoted from AUKraut:
Random Minor Villains as a configurable setting would *definitely* be a welcome change! Keep them in the season, i.e. first minor villain from Season 1, second from Season 2, third from Season 3, then start back on Season 1 again! That would definitely be a rethink in gameplay strategy!
Maybe Lyman still reads Pinside every now and then....
Random minor villains would interesting, but it would also mean that most strategy goes out the window. It's also something that wouldn't work with tournament play. If you really want random minors, just close your eyes when you pick something