I have nearly sold X-Men twice now, and both times (thankfully) got cold feet. A few plays always reminds me that it's one of my favorites and that I am insane for thinking about letting it go. It's such a total package game...tons of satisfying shots, great challenging rules, amazing art, cool theme, and packed with great toys/gimmicks (in the LE at least, IMHO). You just can't beat it. If I ever do let it go, I'm sure I will regret it.
I did go through with selling a Star Trek premium. I regretted it almost instantly and two years later bought a pro that is likely going to stay bolted to the floor. No regrets "downgrading" to the pro and the extra money helped fund other machines, so that one worked out well in the end. Of course the big software update happened between selling the premium and buying the pro, and that definitely helped it become a keeper.